مکانیسم اثر شیتاکه جهت مقابله با بیماری های ویروسی

مکانیسم اثر شیتاکه جهت مقابله با بیماری های ویروسی

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Shiitake mushroom supplementation enhanced gut immunity by upregulating interleukin (IL)-23 secretion in a murine model of acute dextran sodium sulfate-colitis (29). Shiitake extracts and the polysaccharide lentinan exerted antiviral effects, by acting on initial replication processes of poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BoHV-1) (31). Another polysaccharide isolated from shiitake exhibited antibacterial effects in mice by increasing T-helper (Th1) cell immunity, resulting in activation of macrophage-mediated immune response (32). The isolated protein lentin exhibited antifungal properties, inhibited proliferation of leukemic cells, and suppressed activity of human immunodeficiency virus-1 (HIV-1) reverse transcriptase (3). Shiitake consumption in adults altered immune function via increased proliferation of gamma delta-T and NK-T cells, increased secretory immunoglobulin A in saliva, increased IL-1alpha, IL-4, IL-10, and tumor necrosis factor (TNF)-α levels, and decreased macrophage inflammatory protein-1alpha/chemokine C-C ligand 3 (MIP-1alpha/CCL3) levels (41). A low-molecular-weight lignin from shiitake inhibits hepatitis C virus by binding to viral apolipoprotein E (apoE) before interacting with cell surface heparan sulfate (38).

Eritadenine from shiitake may exert antihypercholemic effects and regulate lipid metabolism by inhibiting S-adenosyl homocysteine hydrolase activity, and both eritadenine and shiitake mushroom supplementation upregulated CYP7A1 mRNA expression which was decreased in hypercholesterolemic mice (39). High doses of shiitake mushroom prevented obesity in rats by increasing plasma triacylglycerol accumulation in the liver (30).

Dried shiitake extract caused apoptosis in human hepatocellular carcinoma (HepG2) cells by mediating caspase-3 and -8 pathways  (21). Inhibition of lung cancer cells by the Latcripin-13 domain isolated from shiitake was shown to be due to apoptotic induction (40). Anticancer effects of the polysaccharide lentinan (1,3 beta-D-glucan) may be due to its ability to suppress cytochrome P450 1A enzymes that are known to metabolize procarcinogens to active forms (2). Polysaccharides SLNT1 and JLNT1 isolated from the mushroom also demonstrated antitumor effects by increasing serum IL-2 levels and TNF-α production, and by inducing apoptosis in tumor cells in mice (33).

کانال تلگرامی زگیل تناسلی و قارچ های دارویی

صفحه اینستاگرام زگیل تناسلی و قارچ های دارویی

جهت تهیه قارچ های فوق در تلگرام به شماره ۰۹۱۲۰۷۰۰۸۵۱ پیام دهید

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